In this fourth episode, Michael A. DiSpezio addresses the first PSA test following surgery and what that means as far as the tumor’s spread. He then presents the basics of cancer in terms of cells and DNA. Then, Michael discusses the likelihood of a man getting prostate cancer and how this disease disproportionately impacts African American men. In addition, he explains why prostate illnesses are also a concern for transwomen. Next, he addresses the DRE, short for digital rectal exam. Finally, Michael concludes this segment with a critical explanation of Gleason patterns, Gleason score and the Gleason grade groups.